PD-L1 regulates genomic stability via interaction with cohesin-SA1 in the nucleus
نویسندگان
چکیده
منابع مشابه
Characterization of the Interaction between the Cohesin Subunits Rad21 and SA1/2
The cohesin complex is responsible for the fidelity of chromosomal segregation during mitosis. It consists of four core subunits, namely Rad21/Mcd1/Scc1, Smc1, Smc3, and one of the yeast Scc3 orthologs SA1 or SA2. Sister chromatid cohesion is generated during DNA replication and maintained until the onset of anaphase. Among the many proposed models of the cohesin complex, the 'core' cohesin sub...
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Cohesin is an essential multiprotein complex that mediates sister chromatid cohesion critical for proper segregation of chromosomes during cell division. Cohesin is also involved in DNA double-strand break (DSB) repair. In mammalian cells, cohesin is involved in both DSB repair and the damage checkpoint response, although the relationship between these two functions is unclear. Two cohesins dif...
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Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain Bioinformatics Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain Centre de Regulació Genòmica (CRG), Barcelona Institute for Science and Technology, Barcelona E-0900...
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ژورنال
عنوان ژورنال: Signal Transduction and Targeted Therapy
سال: 2021
ISSN: 2059-3635
DOI: 10.1038/s41392-021-00463-0